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Capricor Therapeutics: Positive 18-Month Results from HOPE-2 Open-Label Extension Study of CAP-1002

January 26, 2023

Capricor Therapeutics has announced positive 18-month results from its ongoing HOPE-2 open-label extension (OLE) study in patients with later-stage Duchenne muscular dystrophy (DMD). Data from the OLE study continues to show evidence for disease modification with statistically significant differences in upper limp performance:

“We are encouraged by the improvements in upper limb function in the treatment group at 18-months and will continue to treat and follow these patients to further evaluate the disease modifying potential of CAP-1002. Taken together, these data build on the impressive results from HOPE-2 and suggest that patients accumulate benefit over time with steady preservation of skeletal muscle functions, which underscore the potential long-term benefit of CAP-1002.”

Dr. Craig McDonald, national Principal Investigator and University of California, Davis, Professor

“In the OLE phase of the HOPE-2 study, we observed statistically significant slowing of the progression of disease across patients treated with CAP-1002. We are extremely pleased by the robust and consistent results observed to date, which, together with the favorable safety/tolerability profile, suggest that CAP-1002 holds promise as a potential anchor therapy for DMD patients.”

Linda Marbán, Ph.D., CEO of Capricor

Read the full press release here: