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What is a nonsense mutation or stop-codon read through?

The first and last exons in a protein carry important information so the protein machinery in the cell knows where to start and stop making a protein. Ten to fifteen percent of individuals with Duchenne have a nonsense stop codon mutation that results in there being a message to stop making the protein in the middle of the protein. This message is called a stop-codon. 

Image depicting exons as puzzle pieces numbered one through seventy-nine
Image depicting premature 'stop' codon on exon six, resulting in no further reading of protein

Click here to learn more about non-sense mutation (stop-codon read through) drugs currently approve or under investigation.