Nonsense Mutations (Stop-Codon Read Through)
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Nonsense Mutations (Stop-Codon Read Through)
The first and last exons in a protein carry important information so the protein machinery in the cell knows where to start and stop making a protein. Ten to fifteen percent of individuals with Duchenne have a nonsense stop codon mutation that results in there being a message to stop making the protein in the middle of the protein. This message is called a stop-codon.
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